DISSOLUTION AND SOLUBILITY ENHANCEMENT STRATEGIES: CURRENT and NOVEL PROSPECTIVES
نویسندگان
چکیده
منابع مشابه
Solubility and Dissolution Enhancement: An overview
Poorly water soluble compounds have solubility and dissolution related bioavailability problems. The dissolution rate is directly proportional to solubility of drugs. Drugs with low aqueous solubility have low dissolution rates and hence suffer from oral bioavailability problems. The poor solubility and poor dissolution rate of poorly water soluble drugs in the aqueous gastro intestinal fluids ...
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INTRODUCTION Solubility is defined in quantitative terms as the concentration of solute in a saturated solution at a certain temperature and pressure. Qualitatively it is defined as the spontaneous interaction of two or more substances to form a homogenous molecular dispersion. The United State Pharmacopoeia (USP) and national formulary lists the solubility of drug as the number of milliliters ...
متن کاملSolubility and Dissolution Enhancement of Silymarin with Fulvic Acid Carrier
Objective: Solubility is a key parameter as it is one of the main causes for poor bioavailability. The objective was to improve the solubility and dissolution profile of poorly-soluble silymarin with a water-soluble carrier fulvic acid. Materials and methods: Phase solubility studies were carried out for the determination of stoichiometric ratio between silymarin and fulvic acid by Higuchi and ...
متن کاملMiniaturization of Drug Solubility and Dissolution Testings
Solubility and drug dissolution are of crucial importance for drug formulations. Poor water-solubility of drug candidates is a major obstacle in drug development, since the oral route is the most patient convenient and cost effective way to deliver drugs. In some cases the low aqueous solubility may limit the bioavailability when the absorption of the drug is dissolution limited. About 40% of t...
متن کاملPreparation and Characterization of Ketoprofen Nanosuspension for Solubility and Dissolution Velocity Enhancement
Nanosuspension technology has been developed as a promising candidate for efficient delivery of hydrophobic drugs. It could maintain the required crystalline state of the drug with reduced particle size, leading to an increased reporting on dissolution rate and therefore improved bioavailability. In this paper, we report on the preparation of ketoprofen (KTF) nanosuspension by high-pressure hom...
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ژورنال
عنوان ژورنال: Journal of Critical Reviews
سال: 2018
ISSN: 2394-5125
DOI: 10.22159/jcr.2018v5i3.23451